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Ionophore Toxicosis
CardiovascularToxicologyEquineNew
Key Points
  • Ionophore toxicosis occurs when an animal ingests an excessive dose of ionophore antibiotics for that species
  • Ionophores are commonly used in poultry and cattle feed as growth promoters and anticoccidials
    • Examples: monensin, lasalocid, salinomycin, narasin
  • Horses are particularly susceptible and even small doses can be fatal
  • Primarily affects cardiac and skeletal muscles so clinical signs reflect myocardial injury and myopathies
  • Diagnosis is typically presumptive, based on clinical presentation and history
  • There is no effective antidote so treatment focuses on decontamination and intensive supportive care
Differential Diagnoses
  1. Equine rhabdomyolysis
  2. Myocarditis
  3. White muscle disease
  4. Atypical myopathy
Overview
Aetiology
Clinical Signs
Diagnosis
Treatment
Prevention
Resources
Overview

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Aetiology

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Clinical Signs

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Diagnosis

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Treatment

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Prevention

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Resources

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Educational content only. This factsheet is for general veterinary education and is not a substitute for professional veterinary advice, diagnosis, or treatment. Not for use in an emergency — contact a veterinarian or emergency service. Full disclaimer →